Shares of Ophthotech Corporation (NASDAQ:OPHT) added 5.77% by the end of trading session at $5.13. For the current quarter, the 9 brokerage firms issuing adjusted earnings per share outlook have a consensus forecast of -$1.68/share, which would compare with -$1.02 in the year-ago quarter. The net percentage change is -91.98% over the last 12 months. The trading range in the same period had a highest hit of $69.82 while lowest level was $4.53. At the moment the price is -78.2% below its 50-day moving average and -88.41% below its 200-day moving average.

Ophthotech Corporation (NASDAQ:OPHT) on December 12, 2016 announced that the pre-specified primary endpoint of mean change in visual acuity at 12 months was not achieved in its two pivotal Phase 3 clinical trials investigating the superiority of Fovista® (pegpleranib) anti-PDGF therapy in combination with Lucentis® (ranibizumab) anti-VEGF therapy compared to Lucentis® monotherapy for the treatment of wet age-related macular degeneration (AMD). The addition of Fovista® to a monthly Lucentis® regimen did not result in benefit as measured by the mean change in visual acuity at the 12 month time point.

The two clinical trials (OPH1002 and OPH1003) were international, multicenter, randomized, double-masked, controlled Phase 3 studies evaluating the safety and efficacy of 1.5 mg of Fovista® administered in combination with Lucentis® (Fovista®combination therapy) compared to Lucentis® monotherapy. In each of these trials, patients were randomized to one of two approximately equal sized treatment groups. The two Phase 3 trials enrolled an aggregate of 1,248 patients with wet AMD. The results from the databases of the two trials were unmasked and analyzed concurrently.

The combined analysis from the two trials (OPH1002 and OPH1003) showed that patients receiving Fovista® combination therapy gained a mean of 10.24 letters of vision on the Early Treatment of Diabetic Retinopathy Study (ETDRS) standardized chart at 12 months, compared to a mean gain of 10.01 ETDRS letters for patients receiving Lucentis® monotherapy, a difference of 0.23 ETDRS letters. In OPH1002, consisting of 619 treated patients, subjects receiving Fovista® combination therapy gained a mean of 10.74 letters of vision on the ETDRS standardized chart at 12 months, compared to a mean gain of 9.82 ETDRS letters in patients receiving Lucentis® monotherapy, a resulting difference of 0.92 ETDRS letters (p=0.44). In OPH1003, consisting of 626 treated patients, subjects receiving Fovista® combination therapy gained a mean of 9.91 letters of vision on the ETDRS standardized chart at 12 months, compared to a mean gain of 10.36 ETDRS letters in patients receiving Lucentis® monotherapy, a resulting difference of -0.44 ETDRS letters (p=0.71). None of these results of the pre-specified primary efficacy analysis were statistically significant.

In the pooled analysis of pre-specified secondary endpoints from both trials, 24.2% of patients receiving Fovista® combination therapy gained 20 or more ETDRS letters from baseline at month 12, compared to 22.1% of patients receiving Lucentis® monotherapy. In OPH1002, 25.9% of patients receiving Fovista® combination therapy gained 20 or more ETDRS letters from baseline at month 12, compared to 20.0% of patients receiving Lucentis® monotherapy. In OPH1003, 22.5% of patients receiving Fovista®combination therapy gained 20 or more ETDRS letters from baseline at month 12, compared to 24.1% of patients receiving Lucentis® monotherapy.

In the pooled analysis, 12.1% of patients receiving Fovista® combination therapy lost 5 or more ETDRS letters from baseline at month 12, compared to 11.2% of patients receiving Lucentis® monotherapy. In OPH1002, 12.0% of patients receiving Fovista®combination therapy lost 5 or more ETDRS letters at month 12, compared to 12.3% of patients receiving Lucentis® monotherapy. In OPH1003, 12.2% of patients receiving Fovista® combination therapy lost 5 or more ETDRS letters at month 12, compared to 10.2% of patients receiving Lucentis® monotherapy.

In addition, in the pooled analysis, 13.5% of patients receiving Fovista® combination therapy achieved visual acuity of 20/25 or better at month 12, compared to 13.9% of patients receiving Lucentis® monotherapy. In OPH1002, 13.6% of patients receiving Fovista® combination therapy achieved visual acuity of 20/25 or better, compared to 13.2% of patients receiving Lucentis® monotherapy. In OPH1003, 13.5% of patients receiving Fovista® combination therapy achieved visual acuity of 20/25 or better, compared to 14.6% of patients receiving Lucentis® monotherapy.

Based on a preliminary analysis of the safety data from these two trials, Fovista®combination therapy and Lucentis® monotherapy were generally well tolerated after one year of treatment. The ocular adverse events more frequently reported in the Fovista®combination therapy group compared to the Lucentis® monotherapy group were mainly related to the injection procedure. The incidence of reported serious systemic adverse events was generally similar in both treatment groups as was the incidence of myocardial infarction or cerebrovascular accident.

Cellectar Biosciences, Inc. (NASDAQ:CLRB) last exchanged hands at a price $1.38/share, registering a gain of 5.73%. Among 2 Wall Street analysts tracked by Thomson/First Call, the average PT for CLRB is $5.07 but some of them are predicting the price to move at the $7.44 level. If the most optimistic analysts are correct, the expected total return from the current price would be 439.13. The number of shares traded in most recent trading day was 1.18M shares which averages 320.28K shares a day. Its previous fifty two week high was $7.4 and moved down -74.35% over the same time frame, currently having a market cap around $13.74 million. Shares have risen -46.53% over the trailing six months. At the moment, the stock trades -12.16% below its 50-day moving average and -43.19% below its 200-day moving average.

Cellectar Biosciences, Inc. (NASDAQ:CLRB) on January 5, 2017 announced that President and CEO, Jim Caruso will present at the Biotech Showcase in San Francisco on January 11, 2017 at 10:00 AM PT in Room 2 (Ballroom Level). Cellectar’s product candidates are built upon its patented cancer cell-targeting delivery and retention platform of optimized phospholipid ether-drug conjugates (PDCs).  The company deliberately designed its phospholipid ether (PLE) carrier platform to be coupled with a variety of payloads to facilitate both therapeutic and diagnostic applications.  The basis for selective tumor targeting of our PDC compounds lies in the differences between the plasma membranes of cancer cells compared to those of normal cells.  Cancer cell membranes are highly enriched in lipid rafts, which are glycolipoprotein microdomains of the plasma membrane of cells that contain high concentrations of cholesterol and sphingolipids, and serve to organize cell surface and intracellular signaling molecules.